Analytical Data
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Gene name
CMC1
- Application
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Alternative Names
CMC1；AGC1；ARALAR1;Electrogenic aspartate/glutamate antiporter SLC25A12. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z7K0
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Expression Region
1-106aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMALDPAD QHLRHVEKDV LIPKIMREKA KERCSEQVQD FTKCCKNSGV LMVVKCRKEN SALKECLTAY YNDPAFYEEC KMEYLKEREE FRKTGIPTKK RLQKLPTSM
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on CMC1 recombinant protein is driven by its significance in understanding the biological processes underlying various cellular functions and its potential applications in therapeutic development. CMC1, or cytochrome c oxidase subunit 1, is a crucial component of the mitochondrial respiratory chain, playing a key role in cellular energy production. Abnormalities in CMC1 expression or function are associated with a variety of diseases, including neurodegenerative disorders and metabolic syndromes. The recombinant production of CMC1 allows for detailed biochemical and structural studies, facilitating the exploration of its interactions with other mitochondrial proteins and its role in electron transport and oxidative phosphorylation. Moreover, generating this protein in a controlled environment provides insights into its enzymatic activity and regulatory mechanisms, which are essential for developing targeted therapies. Current research focuses on optimizing expression systems for higher yield and functionality, investigating post-translational modifications, and examining its implications in pathophysiological contexts. By elucidating the molecular mechanisms involving CMC1, researchers aim to identify potential biomarkers for disease progression and novel therapeutic strategies for mitochondrial dysfunction-related conditions.
