Analytical Data
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Gene name
VPS13A
- Application
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Alternative Names
Chorea-acanthocytosis protein Chorein
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96RL7
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Expression Region
3037-3140aa
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Molecular Weight
28.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
VPS13A is a gene that encodes a protein involved in cellular processes such as membrane trafficking, lipid metabolism, and mitochondrial function. Mutations in VPS13A have been associated with Chorea-Acanthocytosis (ChAc), a rare neurodegenerative disorder characterized by movement abnormalities, cognitive decline, and specific morphological changes in red blood cells. The understanding of VPS13A's function and its role in disease mechanisms is critical for developing therapeutic strategies. Research has highlighted the protein's involvement in the regulation of the endolysosomal system and its potential impacts on neuronal health. Recent studies have employed recombinant VPS13A proteins to elucidate its functional characteristics, structure, and interactions with other cellular components, thereby providing insights into how disruptions in its function can lead to neurodegeneration. Investigating VPS13A is vital for understanding the pathophysiology of ChAc and may hold promise for identifying novel targets for intervention, ultimately aiming to improve patient outcomes and quality of life for those affected by this debilitating condition.
