Analytical Data
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基因名
GLMN
- Application
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别名
GLMN；FAP48；FAP68；VMGLOM；Glomulin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92990
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表达区间
2-594aa
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氨基酸序列
AVEELQSII KRCQILEEQD FKEEDFGLFQ LAGQRCIEEG HTDQLLEIIQ NEKNKVIIKN MGWNLVGPVV RCLLCKDKED SKRKVYFLIF DLLVKLCNPK ELLLGLLELI EEPSGKQISQ SILLLLQPLQ TVIQKLHNKA YSIGLALSTL WNQLSLLPVP YSKEQIQMDD YGLCQCCKAL IEFTKPFVEE VIDNKENSLE NEKLKDELLK FCFKSLKCPL LTAQFFEQSE EGGNDPFRYF ASEIIGFLSA IGHPFPKMIF NHGRKKRTWN YLEFEEEENK QLADSMASLA YLVFVQGIHI DQLPMVLSPL YLLQFNMGHI EVFLQRTEES VISKGLELLE NSLLRIEDNS LLYQYLEIKS FLTVPQGLVK VMTLCPIETL RKKSLAMLQL YINKLDSQGK YTLFRCLLNT SNHSGVEAFI IQNIKNQIDM SLKRTRNNKW FTGPQLISLL DLVLFLPEGA ETDLLQNSDR IMASLNLLRY LVIKDNENDN QTGLWTELGN IENNFLKPLH IGLNMSKAHY EAEIKNSQEA QKSKDLCSIT VSGEEIPNMP PEMQLKVLHS ALFTFDLIES VLARVEELIE IKTKSTSEEN IGIK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GLMN, or Geranylgeranyltransferase type I (GGTase-I), is an essential enzyme involved in the post-translational modification of proteins through the addition of geranylgeranyl groups, which play a critical role in the membrane localization and functionality of numerous signaling proteins, particularly in the Rho family of GTPases. The research surrounding GLMN and its recombinant protein has gained significant attention due to its potential implications in various diseases, including cancer and cardiovascular disorders, where aberrant signaling pathways and lipid modifications are prevalent. Understanding the structure and function of GLMN is crucial not only for elucidating the molecular mechanisms underlying these diseases but also for identifying potential therapeutic targets. Recombinant GLMN protein allows for the establishment of in vitro and in vivo models to study the enzyme's activity, inhibition, and interaction with substrates and signaling pathways. Furthermore, the development of GLMN inhibitors could pave the way for novel treatment strategies that disrupt abnormal Rho signaling, further highlighting the importance of this enzyme in biomedical research. By advancing our knowledge of GLMN's role in cellular contexts, researchers aim to uncover new insights into its biochemical functions and therapeutic potential, establishing a foundational understanding for future clinical applications.
