Analytical Data
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基因名
CETN1
- Application
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别名
CETN1;CEN1;CETN;Centrin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12798
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表达区间
1-172aa
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氨基酸序列
MASGFKKPSAASTGQKRKVAPKPELTEDQKQEVREAFDLFDVDGSGTIDAKELKVAMRALGFEPRKEEMKKMISEVDREGTGKISFNDFLAVMTQKMSEKDTKEEILKAFRLFDDDETGKISFKNLKRVANELGENLTDEELQEMIDEADRDGDGEVNEEEFLRIMKKTSLY
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分子量
46.6kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CETN1, or Centrin 1, is a member of the centrin protein family, which plays a significant role in various cellular processes, including cell division and the regulation of the centrosome cycle. Research into CETN1 has gained attention due to its involvement in the formation and maintenance of microtubule-organizing centers, which are crucial for proper mitotic spindle formation and accurate chromosome segregation. Dysregulation of CETN1 has been associated with several diseases, including certain cancers, where abnormal centrosome function can lead to chromosomal instability. Additionally, CETN1 is implicated in several developmental processes and is essential for the function of cilia and flagella in various cell types. Recent studies have focused on the molecular mechanisms underlying CETN1's role in these biological processes, and researchers have explored its potential as a therapeutic target. By using recombinant CETN1 proteins in vitro, scientists aim to dissect its interactions with other cellular components and to better understand its function in both normal and pathological states. Understanding the structure and function of CETN1 could provide insights into its broader implications in cell biology and disease, as well as pave the way for novel therapeutic approaches targeting centrosome-related disorders. Overall, the study of CETN1 continues to be a promising and dynamic field, with potential implications for understanding fundamental cellular mechanisms and developing innovative treatments for related diseases.












