Analytical Data
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基因名
NPTXR
- Application
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别名
NPTXR；Neuronal pentraxin receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95502
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表达区间
1-500aa
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氨基酸序列
MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGADNASVASGAAASPGPQRSLSALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA
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分子量
52.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NPTXR, or Neuronal Pentraxin Receptor, is a member of the pentraxin family of proteins, which are known for their roles in various physiological and pathological processes, particularly in the nervous system. The interest in NPTXR has surged due to its involvement in synaptic function and plasticity, as well as its potential implications in neurodevelopmental and neurodegenerative disorders. Studies have shown that NPTXR participates in the formation and stabilization of synapses by binding to ligands such as neuronal pentraxins, which are crucial for the uptake of glutamate and other neurotransmitters at synaptic sites. Furthermore, dysregulation of NPTXR expression and function has been linked to conditions such as Alzheimer's disease, schizophrenia, and autism spectrum disorders. The recombinant production of NPTXR protein allows for detailed biochemical and biophysical analysis, facilitating the exploration of its structural characteristics and interaction with various molecular partners. This research holds promise for enhancing our understanding of synaptic mechanisms and developing potential therapeutic targets for neurological diseases.
