Analytical Data
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Gene name
NPTX2
- Application
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Alternative Names
NPTX2；Neuronal pentraxin-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P47972
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Expression Region
1-431aa
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AA Sequence
MLALLAASVALAVAAGAQDSPAPGSRFVCTALPPEAVHAGCPLPAMPMQG GAQSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGG KARGAGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLEHQLRANVS NAGLPGDFREVLQQRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTES TLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAF TICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQL PLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVL ILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPG NIIPWVDNNVDVFGGASKWPVETCEERLLDL
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Molecular Weight
73 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NPTX2, or Neuronal Pentraxin 2, is a member of the neuronal pentraxin family, which plays a crucial role in synaptic function and neuronal communication. This protein is predominantly expressed in the central nervous system and is implicated in various neurological processes, including synaptic plasticity, memory formation, and the clearance of apoptotic cells. Research has shown that NPTX2 is involved in the modulation of synaptic strength and may contribute to the pathophysiology of neurodegenerative diseases, such as Alzheimer's disease and schizophrenia. Given its importance in neuronal signaling, the recombinant expression of NPTX2 facilitates the investigation of its biochemical properties, interactions with other synaptic proteins, and its role in synapse development and maintenance. By studying NPTX2 in a controlled laboratory setting, researchers aim to uncover the molecular mechanisms underlying synaptic dysfunction associated with various neurological disorders. Furthermore, recombinant NPTX2 protein can serve as a valuable tool for the development of therapeutic strategies aimed at restoring synaptic integrity and function in affected individuals. Thus, the investigation of NPTX2 not only enhances our understanding of synaptic biology but also holds potential for identifying novel targets for drug development in the realm of neuropsychiatric disorders.
