Analytical Data
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基因名
CENPP
- Application
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别名
CENPP；Centromere Protein P
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6IPU0
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表达区间
1-288aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MDAELAEVRA LQAEIAALRR ACEDPPAPWE EKSRVQKSFQ AIHQFNLEGW KSSKDLKNQL GHLESELSFL STLTGINIRN HSKQTEDLTS TEMTEKSIRK VLQRHRLSGN CHMVTFQLEF QILEIQNKER LSSAVTDLNI IMEPTECSEL SEFVSRAEER KDLFMFFRSL HFFVEWFEYR KRTFKHLKEK YPDAVYLSEG PSSCSMGIRS ASRPGFELVI VWRIQIDEDG KVFPKLDLLT KVPQRALELD KNRAIETAPL SFRTLVGLLG IEAALESLIK SLCAEENN
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CENPP (Centromere Protein P) is a crucial component of the centromere, a specialized region of chromosomes essential for accurate chromosome segregation during cell division. Research on CENPP has gained increasing attention due to its significant role in maintaining genomic stability and its implications in various diseases, including cancer. CENPP is involved in the assembly and maintenance of the kinetochore, the protein structure on the chromosome that attaches to spindle fibers during mitosis and meiosis. Recent studies have highlighted that CENPP dysfunction may lead to improper chromosome segregation, resulting in aneuploidy and contributing to tumorigenesis. Additionally, CENPP has been linked to the regulation of gene expression and cellular responses to DNA damage, further underscoring its importance in cell biology. Understanding the structural and functional aspects of CENPP through recombinant protein studies can provide insights into its role in centromere dynamics and its potential as a therapeutic target. This research area aims to elucidate the molecular mechanisms underlying CENPP function and its interactions with other centromere-associated proteins, paving the way for novel strategies in cancer treatment and genomic research. As a result, the investigation of CENPP recombinant proteins is poised to uncover critical pathways in cell division and contribute to advances in biomedical science.
