Analytical Data
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Gene name
Nrg
- Application
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Species
Drosophila melanogaster
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Source
Baculovirus
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20241
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Expression Region
610-814aa
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Molecular Weight
28.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Nrg (Neuregulin) is a family of growth factors that play vital roles in various biological processes, including neural development, cardiac function, and the regulation of cell signaling pathways. The study of Nrg and its recombinant (recombinant Nrg proteins) counterparts has gained significant attention due to their potential therapeutic applications in treating neurodegenerative diseases, cardiovascular disorders, and certain types of cancer. Research has revealed that Nrg binds to ErbB receptors, triggering downstream signaling cascades that influence cell survival, differentiation, and proliferation. Disruptions in Nrg signaling have been implicated in conditions such as schizophrenia and heart failure, highlighting the importance of understanding its mechanisms. The development of recombinant Nrg proteins allows for the exploration of their biological functions and therapeutic potential in controlled environments. Moreover, these studies aim to elucidate the structure-function relationships of Nrg, which can aid in the design of targeted treatments. Overall, the investigation of Nrg and its recombinant variants stands at the forefront of biomedical research, offering promising avenues for innovative therapies in a range of diseases.
