Analytical Data
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基因名
CENPQ
- Application
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别名
CENPQ；C6orf139；Centromere Protein Q
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7L2Z9
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表达区间
1-268aa
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氨基酸序列
MSGKANASKK NAQQLKRNPK RKKDNEEVVL SENKVRNTVK KNKNHLKDLS SEGQTKHTNL KHGKTAASKR KTWQPLSKST RDHLQTMMES VIMTILSNSI KEKEEIQYHL NFLKKRLLQQ CETLKVPPKK MEDLTNVSSL LNMERARDKA NEEGLALLQE EIDKMVETTE LMTGNIQSLK NKIQILASEV EEEEERVKQM HQINSSGVLS LPELSQKTLK APTLQKEILA LIPNQNALLK DLDILHNSSQ MKSMSTFIEE AYKKLDAS
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分子量
33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CENPQ is a protein that plays a crucial role in the assembly and maintenance of the centromere, a vital region of chromosomes responsible for proper segregation during cell division. Research into CENPQ has gained significance due to its implications in genomic stability and its potential association with various diseases, including cancer. As a part of the centromere complex, CENPQ interacts with other centromeric proteins, contributing to the formation of the kinetochore, which is essential for the accurate alignment and distribution of chromosomes during mitosis and meiosis. The study of CENPQ and its functional mechanisms is imperative to understand how disruptions in centromere dynamics can lead to aneuploidy and tumorigenesis. Recent advancements in molecular biology techniques, such as CRISPR-Cas9 for gene editing and advanced imaging methods for observing protein interactions in live cells, have facilitated a more profound investigation into CENPQ’s role. Understanding its structure, function, and interaction network not only sheds light on fundamental cellular processes but may also reveal novel therapeutic targets for diseases linked to chromosomal instability. Given the critical nature of centromeres in maintaining genetic integrity, ongoing research into CENPQ is vital for delineating its contribution to chromosome biology and the potential consequences of its dysregulation in human health.
