Analytical Data
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Gene name
NEUROD6
- Application
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Alternative Names
NEUROD6；ATOH2；BHLHA2；Neurogenic differentiation factor 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96NK8
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Expression Region
1-337aa
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AA Sequence
MLTLPFDESV VMPESQMCRK FSRECEDQKQ IKKPESFSKQ IVLRGKSIKR APGEETEKEE EEEDREEEDE NGLPRRRGLR KKKTTKLRLE RVKFRRQEAN ARERNRMHGL NDALDNLRKV VPCYSKTQKL SKIETLRLAK NYIWALSEIL RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC LQLNARSFLM GQGGEAAHHT RSPYSTFYPP YHSPELTTPP GHGTLDNSKS MKPYNYCSAY ESFYESTSPE CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NEUROD6, a member of the NeuroD family of basic helix-loop-helix transcription factors, plays a crucial role in the development and function of the nervous system. Research has shown that NEUROD6 is involved in the differentiation of neuronal precursor cells into mature neurons, making it a key player in neurogenesis and potential regeneration following neural injuries. The protein's ability to regulate gene expression during the neuronal differentiation process suggests its importance not only in neurodevelopment but also in neurological disorders and conditions such as neurodegeneration and brain injuries. Recent studies have focused on the production of recombinant NEUROD6 proteins to investigate their structural and functional properties further. By creating a recombinant version of the NEUROD6 protein, researchers aim to elucidate its binding characteristics, target gene specificity, and the signaling pathways it influences in neural cells. These investigations may ultimately provide insights into therapeutic approaches for promoting neural regeneration and treating various neurodegenerative diseases. Overall, the study of recombinant NEUROD6 serves as a valuable approach to better understand the complexities of neural development and the potential for regenerative medicine in neurology.
