Analytical Data
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基因名
STK39
- Application
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别名
STK39；PASK；SPAK；STE20/SPS1-related proline-alanine-rich Protein kinase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UEW8
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表达区间
1-545aa
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氨基酸序列
MAEPSGSPVH VQLPQQAAPV TAAAAAAPAA ATAAPAPAAP AAPAPAPAPA AQAVGWPICR DAYELQEVIG SGATAVVQAA LCKPRQERVA IKRINLEKCQ TSMDELLKEI QAMSQCSHPN VVTYYTSFVV KDELWLVMKL LSGGSMLDII KYIVNRGEHK NGVLEEAIIA TILKEVLEGL DYLHRNGQIH RDLKAGNILL GEDGSVQIAD FGVSAFLATG GDVTRNKVRK TFVGTPCWMA PEVMEQVRGY DFKADMWSFG ITAIELATGA APYHKYPPMK VLMLTLQNDP PTLETGVEDK EMMKKYGKSF RKLLSLCLQK DPSKRPTAAE LLKCKFFQKA KNREYLIEKL LTRTPDIAQR AKKVRRVPGS SGHLHKTEDG DWEWSDDEMD EKSEEGKAAF SQEKSRRVKE ENPEIAVSAS TIPEQIQSLS VHDSQGPPNA NEDYREASSC AVNLVLRLRN SRKELNDIRF EFTPGRDTAD GVSQELFSAG LVDGHDVVIV AANLQKIVDD PKALKTLTFK LASGCDGSEI PDEVKLIGFA QLSVS
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STK39, also known as serine/threonine kinase 39, is a protein that belongs to the STE20/SPS1 family of kinases, which play critical roles in a variety of cellular processes, including stress response, apoptosis, and cell proliferation. Research on STK39 has gained attention due to its potential involvement in various physiological and pathological conditions, including diabetes, cardiovascular diseases, and cancer. Its kinase activity is believed to regulate several downstream signaling pathways, particularly those related to the AMP-activated protein kinase (AMPK) pathway, which is crucial for energy homeostasis. Additionally, STK39 has been implicated in inflammatory responses and cell differentiation, making it a target of interest in understanding the molecular mechanisms underlying these processes. Recent studies have focused on the structural characterization and functional analysis of STK39, utilizing recombinant protein technologies to produce and purify the protein for further investigation. This research aims to elucidate the specific substrates of STK39 and its role in modulating cellular processes, which could lead to the development of targeted therapies for diseases where STK39 is dysregulated. Understanding the functional dynamics of STK39 at a molecular level may provide valuable insights into its potential as a therapeutic target, as well as its broader implications in human health and disease.
