Analytical Data
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Gene name
CCL15
- Application
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Alternative Names
CCL15；MIP5；NCC3；SCYA15；C-C motif chemokine 15
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q16663
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Expression Region
46-113aa
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AA Sequence
SFHFAADCCT SYISQSIPCS LMKSYFETSS ECSKPGVIFL TKKGRQVCAK PSGPGVQDCM KKLKPYSI
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Molecular Weight
7.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCL15, also known as macrophage inflammatory protein-1 gamma (MIP-1γ), is a chemokine belonging to the CC subfamily that plays a critical role in immune responses and inflammation. It is primarily produced by various immune cells, including monocytes, and is involved in the recruitment of leukocytes to sites of injury or infection. Research has indicated that CCL15 may have implications in several pathological conditions, particularly in cancer, where it can influence tumor microenvironments and contribute to tumor progression and metastasis. Furthermore, studies have suggested that CCL15 could serve as a potential biomarker for certain diseases and a therapeutic target in immunological therapies. The recombinant production of CCL15 protein has become pivotal in these investigations, allowing for the detailed study of its biological functions and mechanisms. Scientists utilize recombinant CCL15 in various experimental setups, including cell signaling assays, migration assays, and in vivo models to explore its effects on immune cell behavior and interactions. Understanding the functions and mechanisms of CCL15 can provide insights into its roles in health and disease, paving the way for novel therapeutic strategies that harness its properties to modulate immune responses in various clinical settings. Thus, the study of recombinant CCL15 protein not only enhances our understanding of chemokine biology but also contributes to the development of innovative approaches for managing inflammatory diseases and cancer.
