Analytical Data
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Gene name
MAP3K7IP1
- Application
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Alternative Names
MAP3K7IP1；MAP3K7IP1；TGF-beta-activated kinase 1 and MAP3K7-binding Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15750
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Expression Region
1-504aa
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AA Sequence
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV VTAP
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MAP3K7IP1, also known as TAK1-binding protein 1 (TAB1), is an important component in the MAPK signaling pathway that plays a crucial role in various cellular processes, including inflammation, apoptosis, and cell proliferation. As a part of the TAK1 complex, MAP3K7IP1 mediates the activation of MAP kinase pathways in response to various stimuli, such as cytokines and stress signals. Research has shown that MAP3K7IP1 interacts with several key proteins, contributing to the regulation of NF-κB and JNK signaling pathways. Dysregulation of MAP3K7IP1 has been associated with various diseases, including cancer, as it influences cellular responses to external factors and aids in cellular survival mechanisms. Given its significant role in these pathways, the recombinant protein of MAP3K7IP1 is studied for its potential applications in therapeutic interventions, targeting inflammation-related disorders and cancers. The production of MAP3K7IP1 as a recombinant protein allows for detailed functional studies, including assessments of its interaction with other signaling molecules, and offers a platform for screening potential inhibitors or modulators. Overall, the exploration of MAP3K7IP1 in the context of its biological functions and implications in disease states continues to be an essential area of research in molecular and cellular biology.
