Analytical Data
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Gene name
SIGLEC12
- Application
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Alternative Names
SIGLEC12；SIGLECL1；SLG；Sialic acid-binding Ig-like lectin 12
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96PQ1
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Expression Region
1-595aa
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AA Sequence
MLLLLLLLPPLLCGRVGAKEQKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGDHVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQNEYTGKMRPISGVTLGAFGGAGATALVFLYFCIIFVVVRSCRKKSARPAVGVGDTGMEDANAVRGSASQGPLIESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQEAIGYEYSEINIPK
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Molecular Weight
64.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Siglec-12 (Sialic acid-binding Ig-like lectin 12) is a member of the Siglec family of receptors, which are known for their roles in immune regulation and cell signaling. This protein is primarily expressed on specific immune cells, such as certain populations of T cells and myeloid cells. Research into Siglec-12 has gained momentum due to its potential implications in immunological disorders, including autoimmune diseases and tumor immunity. Unlike other Siglecs, Siglec-12 shows distinct expression patterns and is thought to contribute to the modulation of immune responses through its interaction with sialic acid-containing glycans on cell surfaces. Animal studies suggest that Siglec-12 may play a role in controlling T cell activation and maintaining immune homeostasis, thus making it a target of interest for therapeutic strategies aimed at enhancing or inhibiting immune responses. Furthermore, the potential for Siglec-12 to serve as a biomarker for certain conditions highlights its relevance in clinical research. As a result, the characterization and production of recombinant Siglec-12 proteins have become essential for understanding its structure-function relationships and developing specific inhibitors or agonists for clinical applications. Ongoing studies aim to elucidate the precise mechanisms of action of Siglec-12 in immune regulation and to explore its therapeutic potential in various disease contexts.
