Analytical Data
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基因名
DNASE1L2
- Application
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别名
DNASE1L2；DHP1；DNAS1L2；Deoxyribonuclease-1-like 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92874
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表达区间
21-299aa
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氨基酸序列
ALRIGAFNIQSFGDSKVSDPACGSIIAKILAGYDLALVQEVRDPDLSAVSALMEQINSVSEHEYSFVSSQPLGRDQYKEMYLFVYRKDAVSVVDTYLYPDPEDVFSREPFVVKFSAPGTGERAPPLPSRRALTPPPLPAAAQNLVLIPLHAAPHQAVAEIDALYDVYLDVIDKWGTDDMLFLGDFNADCSYVRAQDWAAIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVACGARLRRSLKPQSATVHDFQEEFGLDQTQALAISDHFPVEVTLKFHR
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分子量
38.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNASE1L2 (Deoxyribonuclease I-like 2) is an important enzyme involved in the degradation of extracellular DNA, playing a crucial role in maintaining cellular homeostasis and immune response. Mutations in the DNASE1L2 gene have been linked to various autoimmune diseases, particularly systemic lupus erythematosus (SLE), highlighting its potential role in the pathogenesis of these conditions. The enzyme is known for its ability to process and eliminate free DNAs from the extracellular environment, which is essential for preventing autoimmune reactions triggered by the accumulation of self-DNA in tissues. Research into recombinant DNASE1L2 proteins has gained momentum, aiming to understand their structural and functional properties, as well as their therapeutic potential. By producing recombinant variants of DNASE1L2, scientists are exploring the enzyme's mechanisms and its interaction with immune cells, which could pave the way for novel treatments for autoimmune disorders and other related diseases. In addition, the optimization of recombinant DNASE1L2 expression systems may allow for large-scale production of this protein, facilitating further studies into its physiological roles and therapeutic applications. Overall, the investigation into DNASE1L2 and its recombinant forms is a significant area of research, promising advancements in our understanding of immune regulation and potential interventions for autoimmune diseases.
