Analytical Data
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Gene name
MTNR1B
- Application
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Alternative Names
MTNR1B；Melatonin receptor type 1B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49286
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Expression Region
1-362aa
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AA Sequence
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
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Molecular Weight
40.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MTNR1B, the melatonin receptor 1B, is a member of the G-protein coupled receptor family, primarily involved in mediating the physiological effects of melatonin, a hormone associated with circadian rhythms and sleep regulation. Research has shown that variations in the MTNR1B gene are associated with an increased risk of type 2 diabetes and impaired glucose metabolism, making it a significant target for understanding metabolic disorders. The exploration of MTNR1B recombinant proteins serves multiple purposes, including elucidating the receptor's structural and functional characteristics, screening for potential drug interactions, and revealing its role in signaling pathways. This is particularly relevant given the receptor's involvement in various biological processes beyond circadian regulation, such as pancreatic function and insulin sensitivity. Developing and utilizing MTNR1B recombinant proteins offers a valuable tool for conducting binding assays, functional studies, and high-throughput screenings, providing insights into the receptor's mechanism and contributing to the identification of new therapeutic strategies for diseases linked to melatonin dysregulation. Additionally, this research can aid in the design of targeted therapies that modulate MTNR1B activity, potentially leading to novel interventions for diabetes and other related metabolic conditions. Overall, studying MTNR1B recombinant proteins holds promise for advancing our understanding of metabolic health and its connection to circadian biology.
