Analytical Data
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Gene name
HYAL2
- Application
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Alternative Names
HYAL2；LUCA2；Hyaluronidase-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q12891
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Expression Region
21-448aa
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AA Sequence
MELKPTAPPI FTGRPFVVAW DVPTQDCGPR LKVPLDLNAF DVQASPNEGF VNQNITIFYR DRLGLYPRFD SAGRSVHGGV PQNVSLWAHR KMLQKRVEHY IRTQESAGLA VIDWEDWRPV WVRNWQDKDV YRRLSRQLVA SRHPDWPPDR IVKQAQYEFE FAAQQFMLET LRYVKAVRPR HLWGFYLFPD CYNHDYVQNW ESYTGRCPDV EVARNDQLAW LWAESTALFP SVYLDETLAS SRHGRNFVSF RVQEALRVAR THHANHALPV YVFTRPTYSR RLTGLSEMDL ISTIGESAAL GAAGVILWGD AGYTTSTETC QYLKDYLTRL LVPYVVNVSW ATQYCSRAQC HGHGRCVRRN PSASTFLHLS TNSFRLVPGH APGEPQLRPV GELSWADIDH LQTHFRCQCY LGWSGEQCQW DHRQAAGG
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Molecular Weight
51 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HYAL2, or Hyaluronidase 2, is an enzyme that plays a pivotal role in hyaluronan degradation, a vital component of the extracellular matrix involved in various biological processes, including cell proliferation, migration, and tissue hydration. As a member of the hyaluronidase family, HYAL2 is primarily expressed in human tissues and has been implicated in several pathological conditions, such as cancer progression, inflammation, and tissue repair. Research into HYAL2 has gained momentum due to its potential therapeutic applications, particularly in oncology, where its activity can influence tumor microenvironments and metastatic behavior. Moreover, understanding HYAL2’s structure and enzymatic mechanisms provides insights into its biological functions and interactions with other molecules. The generation of recombinant HYAL2 proteins has facilitated detailed studies of its enzymatic properties, substrate specificity, and regulatory pathways, ultimately contributing to the development of novel treatments that harness its enzymatic activity for drug delivery and tissue engineering. As such, the investigation of HYAL2 not only enhances our comprehension of hyaluronan biology but also opens new avenues for targeted interventions in diseases where hyaluronan metabolism is altered.
