Analytical Data
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基因名
BOLA1
- Application
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别名
BOLA1；BolA-like Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y3E2
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表达区间
21-137aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSQGSAGSG AIGPVEAAIR TKLEEALSPE VLELRNESGG HAVPPGSETH FRVAVVSSRF EGLSPLQRHR LVHAALAEEL GGPVHALAIQ ARTPAQWREN SQLDTSPPCL GGNKKTLGTP
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分子量
14 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BOLA1 (Bola family member 1) is a protein that plays a critical role in cellular processes, particularly in the context of iron metabolism and hemoglobin biosynthesis. Research has shown that BOLA1 is involved in the assembly of heme groups, essential components of hemoglobin, and is linked to various hematological disorders when dysregulated. The protein has garnered attention due to its significant implications in diseases such as anemia and thalassemia, where inefficient hemoglobin production leads to severe health complications. Recent studies have focused on understanding BOLA1's structure and function at a molecular level, aiming to uncover its interaction mechanisms with iron and other ligands involved in heme synthesis. The development of recombinant BOLA1 proteins facilitates experimental investigations, allowing researchers to explore its biophysical properties and assess its potential as a therapeutic target. By elucidating the pathways involving BOLA1, scientists hope to gain insights into novel treatment strategies for related disorders and improve our understanding of fundamental biological processes associated with iron homeostasis and red blood cell formation.
