Analytical Data
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Gene name
HIPK2
- Application
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Alternative Names
HIPK2；Homeodomain-interacting Protein kinase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H2X6
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Expression Region
1-640aa
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AA Sequence
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKV YSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASS TSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEH PPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYE VLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARL STESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSA SHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPL YPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREF IDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEI CKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTG
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Molecular Weight
98kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HIPK2 (Homeodomain-Interacting Protein Kinase 2) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cellular stress response, apoptosis, and differentiation. The study of HIPK2 has gained significant attention due to its involvement in cancer biology and its potential as a therapeutic target. Aberrant HIPK2 expression has been linked to several types of malignancies, highlighting its role in tumor suppression and progression. Research on recombinant HIPK2 protein seeks to elucidate its molecular mechanisms and regulatory pathways, which could lead to the development of novel cancer therapies. The recombinant form allows for detailed biochemical assays, structural studies, and the exploration of its interactions with other proteins. Moreover, understanding HIPK2's function in the context of stress signaling pathways provides insights into its dual role as a promoter of apoptosis in response to genomic instability while also influencing cell survival. Given the complexity of its regulatory functions, the generation of recombinant HIPK2 provides a valuable tool for dissecting its contribution to cellular signaling networks, further advancing the field of targeted cancer therapies and drug discovery.
