Analytical Data
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Gene name
BAFF
- Application
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Alternative Names
BAFF；BAFFR；BR3；Tumor necrosis factor receptor superfamily member 13C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y275
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Expression Region
134-285aa
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AA Sequence
AVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
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Molecular Weight
46.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BAFF (B-cell activating factor), also known as BLyS (B lymphocyte stimulator), is a crucial cytokine in the regulation of B-cell survival, differentiation, and proliferation. Its importance in the immune system has made it a significant target for research, particularly in the context of autoimmune diseases and cancers, where BAFF is often found to be dysregulated. Elevated levels of BAFF are associated with several conditions, including systemic lupus erythematosus (SLE) and other B-cell malignancies, leading to increased B-cell survival and altered immune responses. Researchers have aimed to develop recombinant BAFF proteins to better understand its biological functions and to explore therapeutic applications. These studies often involve the characterization of BAFF’s interactions with its receptors, BAFF-R, TACI, and BCMA, which play distinct roles in B-cell biology. Understanding these interactions provides insights into the signaling pathways that govern B-cell homeostasis and can reveal potential targets for drug development. Moreover, recombinant BAFF proteins can serve as tools to evaluate immune responses in preclinical models, paving the way for innovative treatments that modulate BAFF levels for therapeutic benefits in autoimmune diseases and related disorders. As such, research on BAFF recombinant proteins is not only pivotal for elucidating the underlying mechanisms of B-cell regulation but also holds promise for the advancement of novel therapeutic strategies.
