Analytical Data
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基因名
DOK3
- Application
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别名
DOK3；Docking Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7L591
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表达区间
1-496aa
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氨基酸序列
MTRGARLRSD ARAQLNQLSL DGGTGSGQKG KCEEFPSSLS SVSPGLEAAA LLLAVTMDPL ETPIKDGILY QQHVKFGKKC WRKVWALLYA GGPSGVARLE SWEVRDGGLG AAGDRSAGPG RRGERRVIRL ADCVSVLPAD GESCPRDTGA FLLTTTERSH LLAAQHRQAW MGPICQLAFP GTGEASSGST DAQSPKRGLV PMEENSIYSS WQEVGEFPVV VQRTEAATRC QLKGPALLVL GPDAIQLREA KGTQALYSWP YHFLRKFGSD KGVFSFEAGR RCHSGEGLFA FSTPCAPDLC RAVAGAIARQ RERLPELTRP QPCPLPRATS LPSLDTPGEL REMPPGPEPP TSRKMHLAEP GPQSLPLLLG PEPNDLASGL YASVCKRASG PPGNEHLYEN LCVLEASPTL HGGEPEPHEG PGSRSPTTSP IYHNGQDLSW PGPANDSTLE AQYRRLLELD QVEGTGRPDP QAGFKAKLVT LLSRERRKGP APCDRP
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DOK3 (Docking Protein 3) is a member of the DOK family of proteins, which play critical roles in cellular signaling pathways and have been implicated in various physiological and pathological processes, including immune response, cancer progression, and metabolic regulation. DOK3 functions primarily as a scaffolding protein, facilitating interactions between signaling molecules, and is known to influence pathways such as phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK). Recent studies have shown that DOK3 can modulate T-cell receptor signaling and affect immune cell activation, highlighting its potential role in autoimmune diseases and immunotherapy. Furthermore, abnormal expression of DOK3 has been associated with several cancer types, suggesting that it could be a novel target for therapeutic intervention. Research on DOK3 recombinant proteins has gained momentum, as scientists aim to elucidate its structure, interaction dynamics, and functional mechanisms. Understanding DOK3 at the molecular level could lead to the development of targeted therapies and provide insights into its role in disease modulation, making it a significant focus in ongoing biomedical research.
