Analytical Data
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基因名
BCAR1
- Application
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别名
BCAR1；CAS；CASS1；CRKAS；Breast cancer anti-estrogen resistance Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56945
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表达区间
1-870aa
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氨基酸序列
MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHG RQGIVPGNRLKILVGMYDKKPAGPGSGPPATPAQPQPGLHAPAPPASQYT PMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSK QTPHHPFPNPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDT RSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYD VPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAA PPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVA DGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPG REPLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPL VQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMED VHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPD GQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQ LKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQ CEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLS RQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERV KELGHSTQQFRRVLGQLAAA
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分子量
120 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BCAR1, or Breast Cancer Anti-Estrogen Resistance 1, is a crucial protein implicated in the development of resistance to anti-estrogen therapies in breast cancer. Its role in cell signaling pathways that mediate cell survival and proliferation has made it a focal point of research in understanding not only breast cancer biology but also the mechanisms underlying therapeutic resistance. The protein interacts with various molecules involved in signaling cascades, including the PI3K/Akt pathway, which is vital for tumor growth and survival. Studies have shown that BCAR1 overexpression is linked to poor clinical outcomes in breast cancer patients, marking it as a potential biomarker for therapy resistance. The recombinant form of BCAR1 has been utilized in various experiments to elucidate its functional characteristics and interactions at the molecular level. Understanding the structural and functional aspects of BCAR1 through recombinant protein studies can pave the way for developing targeted therapeutic strategies aimed at overcoming resistance in breast cancer treatment. The exploration of BCAR1 not only aids in refining cancer prognostics but also enhances the potential for personalized medicine approaches in managing breast cancer more effectively.
