Analytical Data
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Gene name
BATF3
- Application
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Alternative Names
BATF3；SNFT；Basic leucine zipper transcriptional factor ATF-like 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NR55
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Expression Region
1-127aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSQGLPA AGSVLQRSVA APGNQPQPQP QQQSPEDDDR KVRRREKNRV AAQRSRKKQT QKADKLHEEY ESLEQENTML RREIGKLTEE LKHLTEALKE HEKMCPLLLC PMNFVPVPPR PDPVAGCLPR
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Molecular Weight
17 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3) is a member of the basic leucine zipper (bZIP) family of transcription factors, which play crucial roles in immune responses and hematopoiesis. It is particularly significant for its role in the differentiation of dendritic cells (DCs), specifically the type of DCs that are essential for initiating and regulating T cell responses against pathogens and tumors. Research has indicated that BATF3 is required for the development of cross-presenting dendritic cells, which are pivotal in presenting antigens to CD8+ T cells. Given its impact on immune system modulation, BATF3 has drawn attention for its potential therapeutic applications in cancer immunotherapy and vaccine development. By producing recombinant BATF3 protein, researchers aim to better understand its structural and functional properties, including its interactions with other proteins and signaling pathways involved in immune cell differentiation. This investigation not only advances the basic understanding of immune regulation but also sets the stage for innovative strategies in enhancing anti-tumor immunity and developing targeted immunotherapies. As a result, BATF3's role in immune system dynamics makes it a valuable target for further exploration in both basic and translational research contexts.
