Analytical Data
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Gene name
ADCY3
- Application
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Alternative Names
ADCY3；KIAA0511；Adenylate cyclase type 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60266
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Expression Region
854-1144aa
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AA Sequence
YYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS
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Molecular Weight
40.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ADCY3, or Adenylate Cyclase 3, is an enzyme that plays a critical role in the conversion of ATP to cyclic AMP (cAMP), a pivotal second messenger involved in various physiological processes, including neuronal signaling and metabolic regulation. Research into ADCY3 has gained momentum due to its implications in neurological disorders, obesity, and other metabolic diseases. Mutations in the ADCY3 gene have been linked to obesity, suggesting that alterations in cAMP signaling may contribute to energy balance and appetite regulation. The study of ADCY3 recombinant protein is essential for understanding its functional mechanisms and interactions within cellular pathways. By producing and characterizing this protein, researchers aim to decipher its role in cAMP-dependent signaling and its potential as a therapeutic target. Furthermore, the investigation of ADCY3's structure-function relationship can shed light on the pharmacological modulation of its activity, potentially leading to novel strategies for treating conditions associated with dysregulated cAMP signaling. Overall, the research on ADCY3 recombinant protein not only enhances our comprehension of its biological significance but also opens avenues for innovative therapeutic developments in metabolic and neurodegenerative diseases.
