Analytical Data
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Gene name
TOMM70A
- Application
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Alternative Names
TOMM70A；KIAA0719；TOM70；TOMM70A；Mitochondrial import receptor subunit TOM70
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O94826
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Expression Region
1-608aa
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AA Sequence
MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWSRQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL
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Molecular Weight
67.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TOMM70A, a member of the translocase of the outer mitochondrial membrane (TOM) complex, plays a critical role in mitochondrial protein import and maintenance. This protein is essential for the proper functioning of mitochondria, which are crucial for energy production, apoptosis, and cellular metabolism. Recent research has highlighted the significance of TOMM70A in various cellular processes, including its involvement in the import of precursor proteins into the mitochondria, interaction with molecular chaperones, and potential roles in mitochondrial biogenesis. Abnormalities in TOMM70A function have been implicated in several diseases, particularly neurodegenerative disorders such as Alzheimer's and Parkinson's disease, where mitochondrial dysfunction is a key factor in disease progression. Understanding the mechanisms of TOMM70A activity and its interactions with other proteins can provide insights into mitochondrial dynamics and the development of therapeutic strategies. The study of TOMM70A recombinant proteins has also gained attention for the potential to elucidate its structure-function relationships and interactions, thereby paving the way for novel approaches to target mitochondrial dysfunction in various pathological conditions. Overall, the investigation of TOMM70A is crucial for advancing our knowledge of mitochondrial biology and its implications for human health.
