Analytical Data
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基因名
TOMM70A
- Application
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别名
TOMM70A；KIAA0719；TOM70；TOMM70A；Mitochondrial import receptor subunit TOM70
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94826
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表达区间
1-608aa
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氨基酸序列
MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWSRQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL
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分子量
67.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TOMM70A, a member of the translocase of the outer mitochondrial membrane (TOM) complex, plays a critical role in mitochondrial protein import and maintenance. This protein is essential for the proper functioning of mitochondria, which are crucial for energy production, apoptosis, and cellular metabolism. Recent research has highlighted the significance of TOMM70A in various cellular processes, including its involvement in the import of precursor proteins into the mitochondria, interaction with molecular chaperones, and potential roles in mitochondrial biogenesis. Abnormalities in TOMM70A function have been implicated in several diseases, particularly neurodegenerative disorders such as Alzheimer's and Parkinson's disease, where mitochondrial dysfunction is a key factor in disease progression. Understanding the mechanisms of TOMM70A activity and its interactions with other proteins can provide insights into mitochondrial dynamics and the development of therapeutic strategies. The study of TOMM70A recombinant proteins has also gained attention for the potential to elucidate its structure-function relationships and interactions, thereby paving the way for novel approaches to target mitochondrial dysfunction in various pathological conditions. Overall, the investigation of TOMM70A is crucial for advancing our knowledge of mitochondrial biology and its implications for human health.
