Analytical Data
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Gene name
CYP26B1
- Application
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Alternative Names
CYP26B1;CYP26A2;P450RAI2;Cytochrome P450 26B1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NR63
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Expression Region
1-512aa
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AA Sequence
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
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Molecular Weight
63.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CYP26B1, a member of the cytochrome P450 superfamily, plays a crucial role in the metabolism of retinoic acid, a derivative of vitamin A that is essential for various biological processes, including embryonic development, cellular differentiation, and tissue homeostasis. Dysregulation of retinoic acid levels has been implicated in several developmental disorders and diseases, such as congenital malformations and cancer. Research on CYP26B1 has gained significant attention due to its potential therapeutic applications in manipulating retinoic acid signaling pathways. The recombinant protein of CYP26B1 has been produced to investigate its enzymatic activity, substrate specificity, and interaction with retinoic acid and other compounds. Understanding the structural and functional characteristics of CYP26B1 may provide insights into its role in physiological and pathological conditions, as well as offer potential targets for drug development aimed at modulating retinoic acid levels in various therapeutic contexts. Additionally, the study of CYP26B1 can contribute to a broader understanding of the cytochrome P450 family and its diverse functions in drug metabolism and xenobiotic detoxification.











