Analytical Data
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基因名
CYP26A1
- Application
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别名
CYP26A1；CYP26；P450RAI1；Cytochrome P450 26A1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43174
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表达区间
1-497aa
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氨基酸序列
MGLPALLASA LCTFVLPLLL FLAAIKLWDL YCVSGRDRSC ALPLPPGTMG FPFFGETLQM VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL GSGCLSNLHD SSHKQRKKVI MRAFSREALE CYVPVITEEV GSSLEQWLSC GERGLLVYPE VKRLMFRIAM RILLGCEPQL AGDGDSEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGMKAR NLIHARIEQN IRAKICGLRA SEAGQGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG GHETTASAAT SLITYLGLYP HVLQKVREEL KSKGLLCKSN QDNKLDMEIL EQLKYIGCVI KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVAEIFTN KEEFNPDRFM LPHPEDASRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RHCDWQLLNG PPTMKTSPTV YPVDNLPARF THFHGEI
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CYP26A1, a member of the cytochrome P450 family, plays a crucial role in the metabolism of retinoic acid, an essential bioactive form of vitamin A that regulates various physiological processes, including embryonic development, cell differentiation, and organogenesis. Dysregulation of retinoic acid levels, often due to altered activity of CYP26A1, has been implicated in several developmental disorders and diseases such as congenital disabilities and cancer. As a result, understanding the function and regulation of CYP26A1 is of significant interest in developmental biology and pharmacology. Researchers aim to characterize this enzyme further through the expression and purification of recombinant CYP26A1 proteins. These studies facilitate the detailed analysis of its enzymatic activity, substrate specificity, and interaction with inhibitors, contributing to the broader understanding of retinoic acid signaling pathways. Furthermore, recombinant CYP26A1 can serve as a valuable tool for drug discovery, allowing scientists to explore potential therapeutic interventions that could modulate retinoic acid levels for treating related disorders. Overall, the investigation of CYP26A1 and its recombinant forms is essential for elucidating its biological significance and potential clinical applications in managing diseases associated with retinoic acid metabolism.
