Analytical Data
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Gene name
KAL1
- Application
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Alternative Names
(Adhesion molecule-like X-linked)(Kallmann syndrome protein)
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23352
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Expression Region
380-614aa
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Molecular Weight
32.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KAL1, also known as Kallmann syndrome 1 protein, plays a critical role in the development of the olfactory system and the reproductive axis. Mutations in the KAL1 gene are linked to Kallmann syndrome, a genetic disorder characterized by the combination of hypogonadotropic hypogonadism and anosmia or hyposmia, reflecting the failure of gonadotropin-releasing hormone (GnRH) neurons to migrate properly during embryonic development. The KAL1 protein is involved in cellular signaling pathways necessary for neuronal migration, and its dysfunction can lead to impaired sexual development and fertility issues. Research on KAL1 recombinant proteins has gained traction as it provides valuable insights into the molecular mechanisms underlying Kallmann syndrome and related conditions. Understanding KAL1’s structure and function could facilitate the development of potential therapeutic strategies for hormone replacement and fertility treatments. Additionally, the study of KAL1's interactions with other proteins and its role in neural development can unveil broader implications in neurobiology and endocrinology. Given the complexity of its functions, the exploration of KAL1 recombinant proteins is not only vital for advancing our knowledge of genetic disorders but also holds promise for innovative approaches to tackling reproductive health issues. This research underscores the significance of KAL1 in both basic biological processes and its potential implications for clinical applications.
