Analytical Data
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Gene name
Rgs14
- Application
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Alternative Names
(RGS14)(RAP1/RAP2-interacting protein)(RPIP1)
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Species
Mouse
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P97492
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Expression Region
1-547aa
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Molecular Weight
67.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS14 (Regulator of G Protein Signaling 14) is a member of the RGS family that plays a crucial role in regulating G protein-coupled receptor (GPCR) signaling pathways, which are pivotal in various physiological processes. Its unique structural features, including a GoLoco motif and a PDZ domain, enable it to interact with multiple signaling molecules, including G proteins and other scaffolding proteins. Recent research has highlighted RGS14's involvement in diverse biological functions, such as neuronal signaling, cell migration, and cancer progression. Given its potential role in modulating GPCR signaling, RGS14 has emerged as a target for therapeutic interventions. Studies have shown that RGS14 can act as a molecular switch, influencing signaling pathways related to diseases like cancer and neurological disorders. Therefore, the engineering of RGS14 recombination proteins provides a valuable tool for dissecting its specific functions and interactions within cellular environments. Understanding the structure-function relationship of RGS14 through recombinant protein studies may elucidate its role in health and disease, paving the way for novel therapeutic strategies targeting GPCR-mediated signaling pathways.
