Analytical Data
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Gene name
PTPA
- Application
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Alternative Names
PP2A, subunit B', PR53 isoform Phosphotyrosyl phosphatase activator
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15257
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Expression Region
2-358aa
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Molecular Weight
60.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPA (Protein Phosphatase 2A regulatory subunit B' alpha) is a crucial protein involved in the regulation of various cellular processes, including cell growth, division, and apoptosis. As a member of the protein phosphatase family, PTPA plays a vital role in dephosphorylating serine and threonine residues on target proteins, thus modulating their activity and function. Research into PTPA has garnered significant interest due to its implications in numerous diseases, particularly cancer, where dysregulation of protein phosphorylation cascades contributes to aberrant cell signaling. Furthermore, PTPA has been implicated in the development of neurodegenerative disorders, highlighting its potential as a therapeutic target. Scientists are actively investigating the structural and functional properties of PTPA, employing techniques such as X-ray crystallography and NMR spectroscopy, to better understand its mechanisms of action. In addition, studies focused on PTPA's interactions with other proteins and its role in cellular signaling pathways are paving the way for novel therapeutic approaches. The ongoing exploration of PTPA’s function and regulation not only enhances our fundamental understanding of cellular signaling but also opens avenues for the development of targeted interventions in disease contexts where PTPA is implicated.
