Analytical Data
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基因名
LUC7L3
- Application
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别名
Cisplatin resistance-associated-overexpressed protein;Luc7AOkadaic acid-inducible phosphoprotein OA48-18cAMP regulatory element-associated protein 1 ;CRE-associated protein 1 ;CREAP-1
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95232
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表达区间
1-79aa
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分子量
13.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LUC7L3, or LUC7-like protein 3, is a member of the LUC7 family of proteins, which are critical for RNA processing and splicing in eukaryotic cells. Understanding LUC7L3 is crucial due to its involvement in the regulation of gene expression and its potential implications in various diseases, including cancer and neurodegenerative disorders. The protein plays a significant role in the formation of spliceosomal complexes, which are essential for the accurate removal of introns from pre-mRNA transcripts. Recent studies have highlighted LUC7L3's interactions with other splicing factors, contributing to its function in pre-mRNA splicing. Additionally, dysregulation of LUC7L3 has been linked to alternative splicing events that can lead to the expression of oncogenic isoforms or loss of tumor suppressor variants. Researchers are increasingly focused on isolating and characterizing LUC7L3 recombinant proteins to elucidate their molecular mechanisms of action and to explore their potential as therapeutic targets. Characterizing the structure-function relationship of LUC7L3 through recombinant protein studies could provide deeper insights into its role in splicing regulation and its involvement in pathological conditions. This research has broader implications for understanding cellular mRNA dynamics and the intricate regulatory networks governing gene expression in health and disease.
