Analytical Data
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Gene name
KDM6A
- Application
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Alternative Names
(Histone demethylase UTX)(Ubiquitously-transcribed TPR protein on the X chromosome)(Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein)([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15550
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Expression Region
1095-1258aa
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Molecular Weight
26.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KDM6A, a member of the lysine-specific demethylase (KDM) family, is known for its role in epigenetic regulation by demethylating histone H3 at lysine 27 (H3K27me3), which is crucial for gene activation. The gene encoding KDM6A is located on the X chromosome, and its mutations and dysregulation have been implicated in various cancers and developmental disorders, particularly in the context of tumorigenesis and X-linked intellectual disability. Research has shown that KDM6A is involved in cellular processes such as differentiation, proliferation, and response to environmental cues, making it a potential target for therapeutic interventions. Its unique expression patterns and functional roles in both embryonic development and adult tissues highlight the importance of KDM6A in maintaining cellular identity and homeostasis. Recent advances in recombinant protein technology have enabled the production of functional KDM6A protein, facilitating in-depth studies of its enzymatic activity, substrate specificity, and interaction with other cellular factors. This emerging research avenue aims to elucidate the mechanistic underpinnings of KDM6A's role in health and disease, paving the way for novel strategies in cancer treatment and regenerative medicine.
