Analytical Data
-
Gene name
PIK3R2
- Application
-
Alternative Names
(PI3-kinase regulatory subunit beta)(PI3K regulatory subunit beta)(PtdIns-3-kinase regulatory subunit beta)(Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta)(PI3-kinase subunit p85-beta)(PtdIns-3-kinase regulatory subunit p85-beta)
-
Species
Human
-
Source
E. coli
-
Tag
N- His-GST
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O00459
-
Expression Region
75-125aa
-
Molecular Weight
36.9 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of PIK3R2, also known as phosphoinositide-3-kinase regulatory subunit 2, has gained significant attention in recent years due to its crucial role in the phosphoinositide 3-kinase (PI3K) signaling pathway, which is integral to various cellular processes, including growth, proliferation, and survival. As a regulatory subunit of PI3K, PIK3R2 interacts with the catalytic subunits to modulate the activity of the enzyme complex, thereby influencing downstream signaling pathways involved in metabolism and cellular responses to extracellular signals. Dysregulation of PIK3R2 has been implicated in a range of pathological conditions, including cancer, obesity, and metabolic disorders, making it a target of interest for therapeutic interventions. Researchers are increasingly focusing on the recombinant production of PIK3R2 to facilitate structural and functional studies, which are essential for understanding its mechanisms of action and potential as a drug target. By generating recombinant PIK3R2 proteins, scientists can conduct detailed biochemical assays, structural analyses, and interaction studies, paving the way for the development of novel inhibitors or modulators. This research not only contributes to the fundamental understanding of PI3K signaling but also holds promise for advancing therapeutic strategies aimed at diseases associated with PIK3R2 dysregulation.
