Analytical Data
-
Gene name
SOX18
- Application
-
Alternative Names
SOX18；Transcription factor SOX-18
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P35713
-
Expression Region
1-384aa
-
AA Sequence
MQRSPPGYGA QDDPPARRDC AWAPGHGAAA DTRGLAAGPA ALAAPAAPAS PPSPQRSPPR SPEPGRYGLS PAGRGERQAA DESRIRRPMN AFMVWAKDER KRLAQQNPDL HNAVLSKMLG KAWKELNAAE KRPFVEEAER LRVQHLRDHP NYKYRPRRKK QARKARRLEP GLLLPGLAPP QPPPEPFPAA SGSARAFREL PPLGAEFDGL GLPTPERSPL DGLEPGEAAF FPPPAAPEDC ALRPFRAPYA PTELSRDPGG CYGAPLAEAL RTAPPAAPLA GLYYGTLGTP GPYPGPLSPP PEAPPLESAE PLGPAADLWA DVDLTEFDQY LNCSRTRPDA PGLPYHVALA KLGPRAMSCP EESSLISALS DASSAVYYSA CISG
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SOX18 is a member of the SRY-related HMG box (SOX) family of transcription factors, which play critical roles in various developmental processes and the regulation of gene expression. Research has revealed that SOX18 is particularly important in the development of the cardiovascular system, lymphatic system, and hair follicles. Mutations in the SOX18 gene are associated with several congenital disorders, including hypotrichosis-lymphedema-telangiectasia syndrome (HLTS), a condition characterized by hair loss, lymphedema, and vascular malformations. Given its pivotal functions, the study of SOX18 and its associated pathways is vital for understanding the underlying mechanisms of these diseases. The recombinant production of SOX18 protein allows for in-depth investigation of its structure and biological activity, facilitating the exploration of its role in cellular processes and potential therapeutic applications. By generating and characterizing recombinant SOX18 protein, researchers aim to elucidate its interactions with other cellular factors and its contributions to developmental signaling pathways, thereby providing insights into both normal physiological and pathological conditions. This research could ultimately contribute to the development of novel strategies for treating conditions linked to SOX18 dysfunction.
