Analytical Data
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基因名
AHSP
- Application
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别名
AHSP；EDRF；ERAF；Alpha-hemoglobin-stabilizing Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZD4
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表达区间
1-102aa
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氨基酸序列
MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS
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分子量
38.8kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AHSP (alpha-hemoglobin-stabilizing protein) is a crucial protein involved in the stabilization of unbound alpha-globin chains, which are often prone to misfolding and aggregation, particularly under oxidative stress conditions. Research on AHSP has gained prominence due to its significant role in erythropoiesis and its potential implications in various hemoglobinopathies, such as sickle cell disease and beta-thalassemia. These disorders are characterized by abnormal hemoglobin synthesis, leading to anemia and other severe complications. Understanding the structure and function of AHSP can provide insights into its mechanism of action in maintaining cellular homeostasis and preventing the toxic effects of free alpha-globin chains. Moreover, studies have highlighted the potential of AHSP as a therapeutic target, aiming to enhance erythrocyte production and alleviate symptoms in patients suffering from hemoglobin-related disorders. Recent advancements in recombinant protein technology have enabled the production of AHSP in a laboratory setting, paving the way for further investigation into its biological functions and therapeutic applications. Overall, AHSP represents an important molecular chaperone that could offer valuable avenues for innovative treatments in the realm of hematological diseases.
