Analytical Data
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基因名
AGRP
- Application
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别名
AGRP；AGRT；ART；；Agouti-related Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00253
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表达区间
21-132aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSHMAQMGLAPMEGIRRPDQALLPELPGL GLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCL GQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT
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分子量
15 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Agouti-related protein (AGRP) is a neuropeptide primarily expressed in the arcuate nucleus of the hypothalamus, playing a crucial role in energy homeostasis and appetite regulation. Research on AGRP has gained momentum due to its involvement in obesity and metabolic disorders, conditions that represent significant public health challenges. AGRP acts as an antagonist to melanocyte-stimulating hormones (MSHs), promoting increased food intake and reduced energy expenditure. This dual role makes AGRP a potential therapeutic target for obesity treatments. The study of AGRP's structure, function, and interaction with other neuropeptides is critical to understanding its mechanisms in appetite regulation. Recent advances in recombinant protein technology have enabled the production of AGRP-related peptides, facilitating in vitro and in vivo studies to unravel its biological functions. These studies offer insights into the signaling pathways influenced by AGRP, helping to elucidate its contribution to the neurobiological basis of feeding behavior. Understanding the pathway of AGRP and its receptors could lead to innovative approaches in managing obesity and related metabolic disorders, making it a significant focus in both basic and clinical research contexts.
