Analytical Data
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基因名
SRY
- Application
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别名
SRY；TDF；Sex-determining region Y Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P48431
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表达区间
1-317aa
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氨基酸序列
MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM
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分子量
50.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The SRY (Sex-determining Region Y) gene is a crucial genetic element located on the Y chromosome, playing a pivotal role in male sex determination in mammals. It encodes a protein known as the SRY protein, which functions as a transcription factor, initiating the development of testes by activating other genes responsible for male differentiation. The study of SRY protein is significant for understanding various aspects of sexual development, embryonic differentiation, and related disorders. Research has highlighted that mutations or aberrations in the SRY gene can lead to disorders of sex development (DSDs), resulting in phenotypic variations such as ambiguous genitalia or complete sex reversal. Furthermore, the SRY protein's ability to interact with various co-factors and other signaling pathways underscores its complexity and importance in developmental biology. Investigations into the structural properties of SRY have revealed how it binds to DNA and regulates gene expression, providing insights into its critical functions beyond sex determination. Understanding the mechanisms by which SRY operates not only enhances our knowledge of reproductive biology but also has implications for clinical genetics, infertility treatments, and the management of DSDs, highlighting the importance of SRY protein research in both basic science and potential therapeutic applications.
