Analytical Data
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Gene name
GAPC1
- Application
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Alternative Names
NAD-dependent glyceraldehydephosphate dehydrogenase C subunit 1
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Species
Arabidopsis thaliana
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P25858
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Expression Region
1-338aa
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Molecular Weight
44.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GAPC1, or GTPase-activating protein for Rac1, is a member of the Rho GTPase-activating protein family, which plays a critical role in modulating Rho GTPase signaling pathways. These pathways are essential for various cellular processes, including cytoskeletal dynamics, cell migration, and proliferation. Recent studies have highlighted GAPC1's potential involvement in various physiological and pathological conditions, including cancer progression and neurological disorders. Understanding the structure and function of GAPC1 is crucial for elucidating its role in these processes. Research has shown that the dysregulation of GAPC1 can lead to aberrant cell signaling, contributing to tumorigenesis and metastasis. Moreover, due to its regulatory functions, GAPC1 has emerged as a potential therapeutic target. Investigating the biochemical properties of GAPC1, including its interaction with other cellular proteins and its influence on downstream signaling pathways, is vital for developing targeted therapies. Additionally, the production of recombinant GAPC1 proteins provides valuable tools for in vitro studies, allowing researchers to explore its mechanistic roles and interactions in a controlled environment. Overall, the study of GAPC1 is significant not only for understanding fundamental cell biology but also for its implications in developing therapeutic strategies for diseases associated with disrupted Rho GTPase signaling.
