Analytical Data
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Gene name
IGSF1
- Application
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Alternative Names
Immunoglobulin-like domain-containing protein 1 (Inhibin-binding protein) (InhBP) (Pituitary gland-specific factor 2) (p120)
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N6C5
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Expression Region
1-1336aa
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Molecular Weight
151.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IGSF1 (Immunoglobulin Superfamily Member 1) is a protein that plays a crucial role in various biological processes, including cell adhesion and signal transduction. Research into IGSF1 has gained significance due to its association with various endocrine disorders, particularly those affecting the hypothalamic-pituitary-gonadal (HPG) axis. Mutations in the IGSF1 gene have been linked to hypogonadotropic hypogonadism and central precocious puberty, drawing attention to its potential role in fertility and sexual development. The study of IGSF1 as a recombinant protein has become a focal point for understanding its functional mechanisms and interactions at the molecular level. By producing IGSF1 in recombinant forms, researchers can investigate its structure-function relationships, binding properties, and effects on signaling pathways. This research not only helps elucidate the physiological roles of IGSF1 but also offers potential therapeutic insights, particularly in conditions arising from its dysfunction. Overall, the exploration of IGSF1 recombinant proteins is critical for advancing our comprehension of its biological significance and therapeutic applications in endocrine health.
