Analytical Data
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Gene name
SGMS1
- Application
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Alternative Names
Medulla oblongata-derived protein （Protein Mob） （Sphingomyelin synthase 1） （Transmembrane protein 23）
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86VZ5
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Expression Region
1-413aa
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Molecular Weight
51.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SGMS1 (Sphingomyelin Synthase 1) is an enzyme that plays a crucial role in the metabolism of sphingolipids, which are essential components of cellular membranes and involved in various cellular processes, including signal transduction, cell differentiation, and apoptosis. The study of SGMS1 is of particular interest due to its implications in various diseases, such as cancer and neurodegenerative disorders, where altered sphingolipid metabolism has been observed. Researchers have focused on the characterization of SGMS1 to understand its enzymatic activity and the regulatory mechanisms governing its expression and function. The recombinant SGMS1 protein serves as a valuable tool for elucidating the molecular pathways in which this enzyme participates, as well as for screening potential therapeutic agents that can modulate its activity. Advances in recombinant DNA technology enable the production of SGMS1 in sufficient quantities, facilitating biochemical assays and structural analysis, which further informs the understanding of its role in health and disease. The exploration of SGMS1's interactions with other biomolecules and its involvement in lipid metabolism continues to unravel its significance in cellular physiology, highlighting its potential as a target for therapeutic intervention in diseases associated with sphingolipid dysregulation.
