Analytical Data
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基因名
INSIG2
- 应用
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别名
Short name: INSIG-2
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5U4
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表达区间
1-225aa
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分子量
32.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
INSIG2 (Insulin-induced gene 2) is a key regulatory protein involved in the modulation of cholesterol homeostasis and lipid metabolism. It plays a crucial role in the sterol-regulated control of lipogenic gene expression, acting primarily in the endoplasmic reticulum (ER) where it interacts with SREBP (Sterol Regulatory Element-Binding Proteins). Over the years, research has highlighted the significance of INSIG2 in maintaining cellular lipid levels and its potential implications in various metabolic disorders, including obesity, type 2 diabetes, and cardiovascular diseases. The study of INSIG2 recombinant protein has gained prominence as it provides insights into the functional mechanisms underlying its action in lipid regulation. Recombinant INSIG2 is utilized to investigate its interactions with other proteins, the impact of mutations on its function, and its role in cellular signaling pathways. Understanding the structure-function relationships of INSIG2 through recombinant protein studies can reveal potential therapeutic targets for metabolic diseases and contribute to the development of novel treatment strategies aimed at restoring lipid balance in affected individuals. This highlights the importance of INSIG2 in metabolic research and underscores the need for further studies to explore the full potential and therapeutic implications of this protein in human health.
