Analytical Data
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Gene name
UBQLN1
- Application
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Alternative Names
Protein linking IAP with cytoskeleton 1;PLIC-1;hPLIC-1
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UMX0
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Expression Region
2-589aa
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Molecular Weight
69.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBQLN1 (Ubiquilin 1) is a multifunctional protein that plays a crucial role in protein quality control and degradation pathways, particularly in the ubiquitin-proteasome system. It acts as a molecular chaperone and plays a key role in targeting misfolded proteins for degradation, thereby maintaining cellular homeostasis. Abnormalities in UBQLN1 have been implicated in various neurodegenerative diseases, such as Alzheimer’s and ALS, where the accumulation of misfolded proteins leads to neuronal cell death. Understanding the precise mechanisms of UBQLN1 function is essential for developing potential therapeutic strategies for these conditions. The study of recombinant UBQLN1, particularly in the context of its structure and interactions with other cellular components, can provide valuable insights into its role in cellular proteostasis. Researchers focus on the expression, purification, and characterization of recombinant UBQLN1 to elucidate its biological functions and potential as a target for drug development. This research can pave the way for novel therapeutic approaches to mitigate the effects of protein aggregation and neurotoxicity associated with various diseases, highlighting the importance of UBQLN1 in maintaining cellular health and preventing neurodegenerative processes.
