Analytical Data
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Gene name
clp1
- Application
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Alternative Names
Polyadenylation factor Clp1;Polynucleotide kinase Clp1;Pre-mRNA cleavage complex II protein Clp1
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Species
Xenopus laevis
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6NS21
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Expression Region
1-439aa
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Molecular Weight
54.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLP1 (Cap-specific Ligation Factor 1) is a critical RNA-binding protein that plays a significant role in RNA metabolism, particularly in the processing and maturation of non-coding RNAs and mRNAs. The study of CLP1 has gained prominence as its dysregulation is associated with various neurological disorders and cancers. Researchers are particularly interested in CLP1's function in the capping process of RNA molecules, which is essential for RNA stability, splicing, and translation. Recent advances in molecular biology techniques, such as CRISPR-Cas9 and high-throughput sequencing, have enabled scientists to dissect the functional roles of CLP1 and its interactions within the cellular environment. Understanding the mechanisms by which CLP1 contributes to RNA processing can provide insights into fundamental biological processes and potential therapeutic targets for diseases where RNA metabolism is perturbed. Consequently, CLP1 is not only a key player in gene expression regulation but also a focal point for research aiming to elucidate the complexities of RNA biology and its implications in health and disease.
