Analytical Data
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Gene name
Romo1
- Application
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Alternative Names
Protein MGR2 homolog (ROS modulator 1)
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Species
Mouse
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P60603
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Expression Region
1-79aa
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Molecular Weight
11.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Romo1 (Reactive Oxygen Species Modulator 1) is an essential protein known for its role in regulating oxidative stress within cells. The link between cellular oxidative stress and various pathologies, including neurodegenerative diseases, cancer, and cardiovascular disorders, has intensified interest in understanding Romo1 functions. Initial studies identified Romo1 as a mitochondrial protein that enhances reactive oxygen species (ROS) production, which plays a crucial role in cellular signaling and apoptosis. This dual function of Romo1, as both a promoter and regulator of ROS, suggests its involvement in maintaining cellular homeostasis and responding to stress. Recent research has expanded our understanding of Romo1's role in various biological processes, including autophagy, inflammation, and senescence. Furthermore, dysregulation of Romo1 expression has been implicated in the progression of several diseases, making it an important target for therapeutic interventions. The study of Romo1 recombinant protein provides a promising avenue for elucidating its mechanisms of action and exploring its potential as a biomarker or therapeutic target in oxidative stress-related conditions. Researchers are focusing on characterizing its structure, interactions, and pathways to develop strategies for modulating Romo1 activity in clinical settings, thus highlighting the significance of Romo1 in both basic and translational research.
