Analytical Data
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Gene name
HGFA/HGF Activator
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简介
HGFA/HGF Activator protein does not possess the conserved residue(s) necessary for propagating feature annotation. HGFA/HGF Activator Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived HGFA/HGF Activator protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
HGF activator; HGFA; Hgfac; MGC138395; MGC138397
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Species
Cynomolgus
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0A2K5TZH3
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Expression Region
Q34-S650
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Protein Length
Full Length of Mature Protein
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Molecular Weight
80-100 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HGF (Hepatocyte Growth Factor) is a crucial cytokine involved in various biological processes such as cell proliferation, migration, and angiogenesis, primarily through its receptor MET. Dysregulation of the HGF/MET signaling pathway is implicated in several pathological conditions, including cancer, fibrosis, and neurodegeneration. To explore the therapeutic potential of targeting this pathway, researchers have focused on HGFA (HGF Activator), a serine protease that plays a pivotal role in the proteolytic activation of HGF from its inactive form. The recombinant form of HGFA has emerged as a vital tool in elucidating the mechanisms governing HGF activation, thereby aiding in the development of novel therapeutic strategies. By enabling the controlled activation of HGF in cell culture and in vivo models, HGFA/HGF Activator recombinant proteins facilitate the investigation of HGF’s role in tissue regeneration and repair. Consequently, this research has opened new avenues for understanding how modulating HGF activity can influence a range of diseases, making HGFA/HGF Activator recombinant proteins an essential component in the field of regenerative medicine and cancer therapy. The ongoing studies emphasize the potential of these proteins not just for academic research, but also for their translational applications in developing targeted therapies aimed at restoring normal physiological function in various disease states.
