Analytical Data
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基因名
DLK-1
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简介
DLK-1, also known as pre adipokine, is a transmembrane-secreted protein with an epidermal growth factor (EGF) -like repeat sequence. DLK-1 regulates the growth of pioneer axons by controlling Wnt signaling. DLK-1 is a cell surface protein expressed in many cancers, including hepatocellular carcinoma, and maybe a potential target for monoclonal antibodies to treat cancer. DLK-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived DLK-1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
pG2; FA1; DLK; DLK1; DLK-1; Pref1; secredeltin; ZOG
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种属
Cynomolgus
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
XP_005562275.1
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表达区间
A24-C306
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蛋白长度
Partial
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分子量
42-52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DLK-1 (Dual Leucine Zipper Kinase 1) is a member of the Mitogen-Activated Protein Kinase (MAPK) family, primarily involved in cellular signaling pathways related to stress response, differentiation, and apoptosis. It has garnered attention in various fields of research, including neurobiology and cancer biology, due to its role in neuronal development and tumorigenesis. The overexpression or aberrant activation of DLK-1 has been linked to the progression of several malignancies, making it a potential therapeutic target. Additionally, DLK-1 is essential for the survival and maturation of specific neuron populations, highlighting its significance in neural regeneration and repair processes. The study of DLK-1 recombinant proteins aims to unravel its functional mechanisms, interactions with other signaling molecules, and its potential as a biomarker or therapeutic target in cancer and neurodegenerative diseases. Current research often focuses on characterizing the structure-function relationship of DLK-1, understanding its regulatory pathways, and exploring its implications in both normal physiology and disease states. As a promising candidate for novel therapeutic interventions, DLK-1 continues to be a focal point in advancing our knowledge of cellular signaling networks and their impact on human health.
