Analytical Data
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Gene name
SUZ12
- Application
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Alternative Names
CHET9; JJAZ1; Chromatin precipitated E2F target 9 protein; Joined to JAZF1 protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15022
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Expression Region
Leu448~Phe639
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Molecular Weight
28kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SUZ12 is a crucial component of the Polycomb Repressive Complex 2 (PRC2), which plays a vital role in epigenetic regulation by mediating gene silencing through histone methylation. Research on SUZ12 has gained prominence due to its involvement in developmental processes and its implications in various cancers. Abnormal expression or mutations of SUZ12 can disrupt normal gene regulatory mechanisms, leading to uncontrolled cell proliferation and tumorigenesis. Studies have demonstrated that SUZ12 interacts with other key proteins within the PRC2 complex, such as EZH2, a histone methyltransferase, and EED, which are essential for the complex's function. Understanding the structural and functional dynamics of SUZ12 and its interactions can provide insights into the molecular pathways that govern stem cell maintenance, differentiation, and the epigenetic landscapes of cancer. Additionally, SUZ12 has been identified as a potential therapeutic target, as inhibiting its function might restore normal gene expression patterns in malignancies. The ongoing research efforts are directed toward elucidating the regulatory mechanisms involving SUZ12, its contribution to epigenetic memory, and the development of small-molecule inhibitors that could modulate its activity for therapeutic benefits. Overall, the study of SUZ12 and its role within PRC2 is crucial for advancing our understanding of both fundamental biological processes and the development of novel cancer therapies.
