Analytical Data
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Gene name
BAMBI/NMA
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简介
BAMBI/NMA protein operates as a negative regulator, exerting inhibitory control over the TGF-beta signaling pathway. It finely tunes the signaling cascade initiated by TGF-beta, impacting cellular responses like proliferation, differentiation, and immune modulation. This regulatory role emphasizes BAMBI/NMA's significance in modulating diverse cellular behaviors, with potential implications in various physiological and pathological contexts. BAMBI/NMA Protein, Human (HEK293, His) is the recombinant human-derived BAMBI/NMA protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
BMP and activin membrane-bound inhibitor homolog; BAMBI; NMA
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q13145
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Expression Region
V21-A152
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Protein Length
Extracellular Domain
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Molecular Weight
16-23 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BAMBI (Bone Morphogenetic Protein and Activin Membrane-bound Inhibitor) and NMA (Nodal Modulator A) are important proteins that play critical roles in various biological processes, particularly in the regulation of embryonic development and cellular signaling pathways. Research into BAMBI/NMA recombinant proteins focuses on understanding their mechanisms of action and interactions within the transforming growth factor-beta (TGF-β) superfamily, which includes important growth factors involved in cell differentiation, proliferation, and tissue homeostasis. BAMBI serves as a pivotal antagonist of bone morphogenetic proteins, mitigating their signaling pathways, while NMA is involved in modulating Nodal signaling, a crucial aspect of mesoderm formation and left-right axis determination during embryogenesis. The study of these recombinant proteins has significant implications, as they could provide insights into congenital disorders, cancer progression, and regenerative medicine. By elucidating their roles and functions, researchers aim to harness their properties for therapeutic applications, including the development of novel drugs and biotechnological tools that target related signaling pathways, thereby advancing our understanding of development and potential interventions in pathological states.
