Analytical Data
-
Gene name
SUPT6H
- Application
-
Alternative Names
SPT6; SPT6H; emb-5; Histone chaperone suppressor of Ty6; Tat-cotransactivator 2 protein; Transcription elongation factor SPT6
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q7KZ85
-
Expression Region
Ile538~Met666
-
Molecular Weight
18kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SUPT6H, a crucial member of the Super Elongation Complex, plays a vital role in the regulation of transcription and gene expression in eukaryotic cells. Initially identified in yeast, this protein is known to facilitate the transition from transcription initiation to elongation, thereby enhancing RNA polymerase II activity and promoting efficient mRNA synthesis. Dysregulation of SUPT6H has been associated with various diseases, including cancer, where aberrant gene expression patterns contribute to tumorigenesis. Recent studies have highlighted its interactions with other key transcriptional regulators and histone modification enzymes, underscoring its importance in chromatin remodeling and the maintenance of histone marks. The recombinant expression of SUPT6H provides a valuable tool for exploring its biochemical properties and functional mechanisms. By producing this protein in vitro, researchers can investigate its structural characteristics, binding affinities, and roles in transcriptional regulation. Furthermore, understanding SUPT6H at the molecular level may reveal potential therapeutic targets for diseases linked to transcriptional dysregulation, offering insights into strategies for modulation of gene expression in various pathological contexts. Overall, the study of SUPT6H recombinant protein is fundamental for unraveling the complexities of transcriptional control and its implications in human health.
