Analytical Data
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Gene name
UBR4
- Application
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Alternative Names
RBAF600; p600; ZUBR1; Zinc Finger,UBR1 Type 1; N-recognin-4; 600 kDa retinoblastoma protein-associated factor; Retinoblastoma-associated factor of 600 kDa
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5T4S7
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Expression Region
Val124~Arg396
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Molecular Weight
34kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UBR4, a member of the UBR family of E3 ubiquitin ligases, has garnered increasing attention in recent years due to its crucial role in protein degradation and cellular homeostasis. It is primarily involved in the ubiquitin-proteasome system, which regulates various cellular processes by tagging defective or misfolded proteins for degradation. Research has shown that UBR4 influences diverse biological functions, including cell cycle regulation, DNA repair mechanisms, and responses to stress, thereby impacting overall cellular health. Dysregulation of UBR4 expression or function has been implicated in several diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Investigating UBR4 recombinant proteins has provided valuable insights into its biochemical properties, functional mechanisms, and interactions with other cellular components. Understanding UBR4's role in proteostasis not only advances our knowledge of fundamental biological processes but also opens avenues for developing interventions in diseases linked to protein mismanagement, making it a significant focus area in molecular and cellular biology research.
